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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

Recipient: President-elect Donald Trump and Hilary Clinton (joint winners)
我们不会越俎代庖,不会超越区域去做不应是中国做的事情。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

This heart is too weak to actually pump blood, which is the primary reason anyone would want an new heart. But the tissue has a lot of potential for patching heart muscles that have suffered damage.
It is the thirdhighest overall behind the two Indian management academies at Ahmedabad and Bangalore, with respective salaries of $109,000 and $106,000.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

10.Selfie Sticks

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

The country has rolled out measures to promote new-energy vehicles, including tax exemptions, subsidies for car purchases and a requirement for government departments to buy more new-energy cars.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

牌类游戏等休闲类游戏在10大热门游戏中占据了三席,仅次于大型多人在线角色扮演游戏;而腾迅QQ游戏等网页游戏正逐渐成为一个新的增长领域。报告说,截至2009年10月底,排名前5位的网页游戏玩家总数达到154万人,玩家平均在线时长为30分钟。
冲击奖项:最佳影片、最佳原创剧本奖项的提名应该是肯定的,而弗兰西斯麦克多蒙德现在是奥斯卡最佳女主角奖的最热人选。
“见风使舵!”“谄媚迎合美国人!”官方入选名单一经宣布,负面评价如潮水般汹涌而来。电影节上影片使用英语对白的导演不在少数,包括了意大利的马提欧?加洛尼(Matteo Garrone)和保罗?索伦蒂诺(Paolo Sorrentino),希腊的欧格斯?兰斯莫斯,挪威的约阿希姆?提尔(Joachim Trier),甚至包括法国的纪洛姆?尼克乐(Guillaume Nicloux)。法国有着对英语威胁极其敏感的文化情结。有一个观点认为,戛纳应该是世界电影的天堂,而英语电影的天堂已经有了,就是好莱坞。但这有意义吗?在戛纳电影节上,除了法语或英语影片,其他影片都是双语字幕--这是个巨大的工程。
单词popular 联想记忆:

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 宜宾汽车产业园项目开工
Perspective

Trends and targets in antiviral phototherapy

The Jungle Book will be released worldwide on April 15, 2016.
立场:支持移民改革
n. 元素,成分,组成部分,(复数)恶劣天气
Think you’ve had some bad job interviews this year? This survey is guaranteed tcheer you up (unless you happen tbe part of it). When staffing firm OfficeTeam asked 600 managers across North America tdescribe the most embarrassing interview blunders they had seen in 2014, here’s what they said.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

At the time of the third presidential debate in October both candidates churlishly refused to greet or bid farewell to the other in the custom of the handshake.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

8.Show Appreciation

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
From the themed collection: 陶瓷家具等企业求保无门
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

《好时光》
Exports to both South Korea and Asean countries fell by about 3 per cent, however, while those to re-exporter Hong Kong dropped by more than 16 per cent.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 北京市开始试水“租购同权”
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

In early 2005, Stone and her co-founders Elisa Camahort Page and Jory Des Jardins noticed that there were countless women blogging, but mainstream media rarely linked to their posts. The trio decided to host a grassroots conference that year and attracted sponsors like Google and Yahoo. It quickly sold out and soon after, they launched BlogHer.com. The publishing platform turned blogging into a lucrative business for many women -- it paid $25 million to 5,000 of its bloggers between 2009 and 2012 -- and now reaches an audience of 92 million.
After the success of The Conjuring, Ed Warren and Lorraine Warren are back to kick some ghost butts. Conjuring 2 is based on the Enfield Poltergeist, which is apparently a true event that took place in London in 1977.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

But there's even more to be excited about: Magic Johnson is a well-connected and well-respected Hall of Famer who seems smart enough to delegate, new GM Rob Pelinka is a proven deal-maker with extensive ties throughout the league,
Foreign investment in emerging markets has dropped to the lowest level since the financial crisis as investors are braced for the fallout of the first US interest rate rise in nearly a decade.

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 燕郊二手房单价普降万元
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Mr Crabb has taken no exposure to Hong Kong’s property market since setting up in Asia 18 months ago, because he says prices are too high and affordability too low.
传统上,在教学和研究水平方面,中国大学在国际排名排行榜上的评价要比美国和欧洲的高校逊色一些。
“所以问题在于你如何将不可能化为可能?如何保证既忠于原始人物和设定,同时不冒犯21世纪的读者?
Its selection of Mr Trump neither accords with the votes cast in the election nor reflects judgment of the candidate’s merits, as desired by Alexander Hamilton.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

自2007年4月以来,全球最具价值品牌100强的品牌价值增长106%。同期标准普尔500指数(S&P 500)和MSCI明晟全球指数(MSCI world index)分别上涨61%和21%。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Apple Inc., Alphabet Inc.'s Google, and Coca-Cola Co. topped the list of the world's 100 most valuable brands in 2016, while technology and automotive brands dominated the overall rankings, according to a new report from brand consultancy Interbrand.
o 特斯拉的规模越大,运营的复杂性就越强。由于它直接销售给终端顾客,免去了特许经销商的环节,它必须开发一个自己的服务中心网络来进行售后维修保养。另外它独特慷慨的保修条款规定,车主在使用三年后,可以以原价50%的价格将车卖还给特斯拉。这种做法可能会催生一个二手特斯拉的专门渠道。“寻找阿尔法”上的一位博主写道:“等到车主觉得他们的车不像一年前那么诱人和罕见,特斯拉可能会吃进大量有三年车龄的二手车。在我看来,这是个潜在的麻烦。”

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Sometimes Anna’s hair, which is lighter than Ms. Chastain’s natural color, is pulled back, creating layers and a bit of playfulness, but still maintaining authority.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 旧楼加装电梯价格立涨?
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

3.Pay no attention to those bow-tied etiquette experts you sometimes see on CNN International, telling you how to behave while in Britain. These people are generally of dubious provenance, normally live in California and tend to peddle advice that is either irrelevant or out of date. For example, they will often say that Britons love queuing and are so fond of apologising that they will often say "sorry" even when something isn't their fault. In reality, Britons are just as likely to jump to the front of a queue and then punch the person behind them for coughing. It all depends on how muggy it is.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

007系列电影主题曲第二名:蒂娜·特纳--《黄金眼》
Regional
节目40 歌曲《难忘今宵》李谷一 张英席 白丽莎(孔子学院学员)、茹丝(孔子学院学员)、李天翼(孔子学院学员)、吴孟天(在华留学生)
Fluctuations of the markets led to a tightening of IPO approval to maintain stability, according to Frank Lyn, PwC China's mainland and Hong Kong Markets Leaders.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

这是充满希望的春天,也是令人绝望的寒冬……
户外空间:这栋房屋占地面积五分之一英亩(约809平方米)由纽约公司Landgarden负责景观设计。房屋前面的这座日式花园中采用了当地的植物。这栋房屋后面还有一处露台和院子,那里还有一座日式花园。
在气候学的史册里,2014年超过了2010年,成为最热的年份。有记录以来的10个最暖年份都是在1997年以后,反映了地球不断变暖的趋势,科学家说,这种变暖是人类活动的结果,并对人类文明和大自然构成了深远的长期危险。
部分在企业界的资助下,该机构将一流毕业生派到面向低收入社区的学校至少两年时间,而且也完全知道,其中许多人将会在这一时期结束后不再从事教学工作。
1月份,沃尔玛美国公司总裁兼首席执行官比尔西蒙承诺,这家全球最大零售企业将在今后五年内聘用10万名老兵。此外,作为美国最大的私营雇主,沃尔玛还表示它将邀请光荣退伍不到一年的老兵加盟公司。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

n. 全体船员,全体乘务员,(一组)工作人员
11 August

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Apple Inc., Alphabet Inc.'s Google, and Coca-Cola Co. topped the list of the world's 100 most valuable brands in 2016, while technology and automotive brands dominated the overall rankings, according to a new report from brand consultancy Interbrand.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

汇丰发布的正式PMI指数从10月份的50.4降至11月份的50.0,这是6个月内的最低读数。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

The One-China policy constitutes the political foundation of China-US relations which has remained unshaken despite the changing circumstances, nor can this relationship be undermined. With that foundation in place, we believe that there are broad prospects for China-US cooperation.
Except your Watson, he thinks it's hot.
最近两年你都没有涨薪水
movement

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

5. Will China's migrant workers get permanent urban residence in 2010?
Best Car Brand: Mazda
As a measure of that fall, 10 works have sold at auction for more than $100 million since 2004, and all of them were made by modern or contemporary artists in the past 120 years. Older paintings have seen their value, in relative terms, level off or decline. The trend was plain to see in recent weeks, as London’s auction houses tried to find buyers for their latest tranche of old masters. As has been the case in recent years, there were few works by major names.
中国富人近年来对岛屿表现出越来越浓厚的兴趣。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

“BlackBerry has not engaged in discussions with Samsung with respect to any possible offer to purchase BlackBerry,” the company said in a statement issued Wednesday afternoon. “BlackBerry’s policy is not to comment on rumors or speculation, and accordingly it does not intend to comment further.”
全球很多国家的消费者都倾向于购买国产货,这帮助推升了本土品牌的品牌价值。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Small circulation also contributed to the monkey stamp's record price. Only five million "Golden Monkey" stamps were released for circulation in 1980, and they are exceedingly rare now.
However, in season two Friends took a big leap toward equality by featuring a gay wedding when Carol married her girlfriend Susan. Behind the scenes, executive producer Marta Kauffman said, "NBC expected thousands and thousands of phone calls and hate mail." However, after the episode aired, they received only four antagonistic letters. As it turns out, people just didn't care that much.
不会。当然,这种情况可能发生,但是只要运气不是太差,梅眼下至少可以确保英国经济不会在2019年因掉落“无协议”悬崖而急剧下滑。2017年12月,“共识预测”(Consensus Forecasts)预测2018年英国将增长1.5%。该机构对日本和意大利的预测值更低,为1.3%。因此英国明年成为G7中经济增长最慢国家的几率应该在四分之一左右。
Cnzz.com的报告还讨论了目前在中国网络游戏行业盛行的装备收费模式问题。举例来说,很多美国游戏公司都是按照时间收费的,但大多数中国网络游戏都采取了装备收费模式,玩家可以免费试玩。用户玩游戏的时间越长,就越有可能花钱购买游戏装备,以获得更高的游戏级别。但这也意味着花钱最多的玩家就在游戏中表现最好。
权且称之为“白”的危机。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

Among the top 50 richest women in the world, entrepreneurs from the Chinese mainland account for 56%.
超过了9月份11.2%的上涨幅度。
4. Outsourcing placement services.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

em进入,brace胳膊-拥抱
Mrs. May’s government proposed a rule that would publicly shame employers who hired foreign workers. And her first major speech was full of barbs directed against multiculturalism, including a jab against people who claimed to be “citizens of the world,” whom she called “citizens of nowhere.”

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 石材行业如何突破物流“瓶颈”
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

Overall twenty-eight thousand bombs and other munitions were exploded over Yugoslavia a country the size of Ohio. William Cohen then secretary of defense characterized Allied Force as “the most precise application of airpower in history.” Some five hundred civilians died in the bombing a remarkably low number for such a high number of munitions expended. In its own account of the campaignNATO stresses that targets were “carefully sexted” and that “massive effort was made to minimise the impact of the air campaign on the Serb civilian population.”
虽然周六欧锦赛中爱尔兰0-3不敌比利时,但这并没有让赴波尔多看球的爱尔兰球迷一蹶不振。
上月,在全国70个大中城市中,新建商品住宅价格环比上涨的有55个,价格持平的有4个,价格下跌的有11个。环比下跌的城市包括深圳(下跌0.3%)、杭州(下跌0.4%)和厦门(下跌0.2%)。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

While the currency exchange limit has not changed, individuals are now required to disclose specific details on how they will use the funds. Funds can only be used towards current account spending such as tourism and shopping, overseas study, foreign medical care and consulting services. Real estate and other investment spending are explicitly forbidden.
Wang Ki-young, a director at South Korea’s culture ministry, said on Friday that Chinese authorities had ordered tourism agencies in Beijing to halt tours to South Korea from mid-March. Mr Wang said the move would be expanded to other provinces.
Starbucks, up 49 per cent to 21 in the ranking, has evolved from a café to a place where people can hang out all day since it now sells breakfast, lunch and evening meals, accompanied by alcohol in some places.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

我们要通过“互联网+政务服务”,让群众少跑腿、少烦心、多顺心。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

The World Cup, on the other hand, was searched for as both a sporting event and a cultural experience.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

productive
6.癌症死亡率

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

一有机会就炫一下小卷毛。
5. 《在杰克逊高地》(In Jackson Heights)。杰出的弗里德里克·怀斯曼(Frederick Wiseman)带来的三个多小时的新作;这或许可以解释为什么奥斯卡奖的蠢材们再一次没有把他加入候选名单。
The best bosses understand the art of delegation. My commenter said something along the lines of, “They’ve fired themselves from their previous job,” meaning that they don’t interfere in the day-to-day and minute-to-minute workflow or processes. In essence, learning to delegate instead of micromanage is about trust。
同期,巴西和俄罗斯分别减持到2617亿美元和1089亿美元。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

Solar Eclipse
安汉德

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 智能马桶统一标准有望年内出台
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

"We have called the police and collected evidence to protect the company's reputation. Those who leaked the nude pictures will be punished according to law," the announcement read.
6.数据科学家

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

If it isn't appropriate to interrupt, make a quick note of your question so you don't forget, and ask later.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
From the themed collection: 建材家装领域近年来成为投诉热点
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

Tumor Biology, a journal published by Springer Nature, announced last week that it had retracted the papers after an investigation showed the peer review process had been compromised.
就毕业3年后的学员薪资而言,德国的管理硕士课程排名居前,有3所商学院进入前4名。奥托贝森管理研究院(WHU Beisheim)的毕业生享有薪酬最高的名声,平均薪资为9.8123万美元。
2013年排名:12
We learned that we could see a source of ripples in space-time.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

Tesla says it enjoys sales per square foot at its showrooms that are double that of Apple . The tech company is currently considered the industry leader.
n. 购买,购买的物品

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

First, the companies that gained the most consumer love ...
James Bond Themes 3. "Skyfall" by Adele
Epic Games在网站Kotaku上发表的一份声明中则指出,提起法律诉讼的原因是罗杰斯在一个YouTube视频的可移除标签上写下了涉及DMCA的反诉内容,这段视频展示并推广了《堡垒之夜》外挂软件。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

专业一点
澳大利亚一名女子将其猫咪们遗弃在家里,最后这些猫咪们竟同类相食,目前该女子已被判虐待动物罪。
5.E-Cigarettes

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

但事实上,作为一项新技术以及新运动,比特币在2014年表现出了猛烈的势头,而且在新的一年有望征服更多怀疑论者。诸多领域的指标证明了这一点:与比特币相关的初创企业和就业岗位数量大增;接受比特币的机构数量也大大增加;开发人员间的活动也较此前增强。
别提什么至少提前两周通知公司,精心安排一次离职面谈,在卷铺盖走人前费尽心机跟人搞好关系了。有些人在离职时太过匆忙,根本顾不上这些套路。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
From the themed collection: 房产证迟几年办有哪些影响
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

福布斯表示,如果不扣除管理费和税费,在2015年6月1日到2016年6月1日期间,全球收入最高的10位女星共入账2.05亿美元。
'In the meantime, the U.S. continues to grow its own domestic production both in oil and gas. I think, for us, it's less about where the actual price is going--it's more about how much more growth is left in North American oil sands, shale gas, shale oil,' as well as shale exploration elsewhere, he said.
她解释说:“这一事件牵涉了许多方面,例如环境、能源、工作场所灾难和大国政府职能。它成为了人们焦虑情绪聚集的一个焦点。”

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

9.Touchscreens
"It's a great conservation success story."

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

My hunch is that this draft will look pretty good by March and will be much better than last year's, which was one of the most underwhelming in recent memory. New Orleans and Washington both need some direction, and soon.
单词facilitate 联想记忆:
2015年最佳职业

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

立场:和员工分享300万美元奖金

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 江宁建材市场商户:承诺变空文
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Yunge from the Desert
Marcos Carvalho, an 18-year-old Brazilian fan who was hanging out near the Estadio Nacional in Brasilia before Brazil played Cameroon earlier this week, said that he "didn't even try getting tickets, they were too expensive.""There was no way we could afford them," he said. "We'll just watch the match at home, it's all we can do. We are seeing everyone going to the stadium, everyone happy, but we won't be going."

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
From the themed collection: 连天红事件何时休?
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Researchers at Google discovered that security questions as a standalone method for recovering access to accounts is not an efficient model.
我们希望看到的亚太地区是一个稳定、有秩序的地区,是一个可以协商一致、达成原则的地区,是一个有能力管控分歧的地区,也是一个有智慧解决争端的地区。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 三棵树河南生产基地正式投产
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

精准加力补短板。
Lighting is key when it comes to getting work done. Instead of investing in your typical, boring college dorm room desk lamp, pick something with a prettier design. Check out vintage stores for one-of-a-kind table lamps or keep it cheap with the Tiffany Table Lamp, $99.99, at Target.com.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
From the themed collection: 陶瓷、卫浴行业三大区别揭秘
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

1. Newspaper reporter
You’re a busy person. At times, it all can feel overwhelming. Asana is a cloud-based project management software that helps you keep it together. (Trust me, I’ve tried them all.) Flexibility is built into Asana’s architecture. Each “task”, or “subtask”, can be associated with a larger “project” and “department.” In addition, you can even assign recurring tasks to yourself or team, which makes life so much easier. Stop trying to remember all the things you’re supposed to do and let Asana structure your life.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Colliding Neutron Stars

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Users say the voice messages are transferred quickly enough to have a conversation on the platform. But different from free voice applications such as Microsoft Corp.'s Skype, it also offers the flexibility of answering messages at a later time. 'I can decide when to reply, or not to,' said Beijing WeChat user Robin Wang.
Since 2005, the business book of the year award has gone to the book that provides “the most compelling and enjoyable insight into modern business issues”. The 2014 winner was Capital in the Twenty-First Century by Thomas Piketty.
在希雅的《Chandelier》、《Elastic Heart》、《Big Girls Cry》3个MV中,都能见到玛蒂的身影。
[?'lju?]

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

明星们的私家飞机刚停稳,“老爹身材”一词便在互联网上走红。男性微胖的身材成为潮流,荧幕上不少这样的例子。法新社(AFP)Deborah Cole(黛博拉?科尔)写道:“杰拉尔?德帕迪约(Gerard Depardieu)在《爱之谷》中的形象便是“大汗淋漓、气喘吁吁地打着赤膊”, 华金?菲尼克斯 (Joaquin Phoenix)在 伍迪?艾伦(Woody Allen)的新片《非理性的人》(Irrational Man)中也露出了他那胖胖的肚子。科林?法瑞尔(Colin Farrell)出席《龙虾》(The Lobster)的首映红毯时,看起来如往常一般衣冠楚楚,然而在剧中他却大腹便便。为了给荒诞主义者欧格斯?兰斯莫斯(Yorgos Lanthimos)的黑色喜剧中的孤独主角增肥,法瑞尔大量进食高热量食品,其中包括融化了的冰淇淋。他告诉《好莱坞报道》(Hollywood Reporter),“在早晨10点享用2个芝士汉堡、薯条和可乐可不那么有趣,”他补充道,“不过我喜欢芝士汉堡。”

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 2018广州楼市主基调:平稳
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

樟宜机场集团总裁李绍贤先生表示:“连续五年获得Skytrax世界最佳机场的殊荣,这是对整个樟宜机场五万多名职员巨大的鼓励,我们每一位员工都极富热情,并且希望留给每一位旅客最难忘的候机经历。”
Colliding Neutron Stars
不过,五家总部驻北京的旅行社表示,他们仍在销售3月份的韩国游产品,而中国最大在线旅游公司携程(Ctrip)也做了同样表态。中国三大国有航空公司的代表向彭博(Bloomberg)表示,他们并未收到要求停止销售赴韩国机票的指示。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

'People in the community are affected by what I write, ' he says.
control

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

I expect more companies to develop leaders who know how to manage networks — not just the traditional internal network of employees, but more loosely connected webs of suppliers and contractors, managed remotely via the internet and social media.
单词discourse 联想记忆:

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

For once, the Lakers are in good spot and don't have to rush into anything. Take some time. See what they have. They're not making the playoffs with that defense, but that's not really the point of this season anyway.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

北京正努力在年底前完成《区域全面经济伙伴关系协定》(Regional Comprehensive Economic Partnership,简称RCEP)。该协议长期以来被称为中国面对《跨太平洋伙伴关系协定》(Trans-Pacific Partnership agreement,简称TPP)的对策,以及代表了中国争取区域贸易霸权的努力。
survey
Yes. The government hasn’t won a vertical merger case in decades. According to the Department of Justice’s own review guidelines, “vertical mergers” between content owners like Time Warner and distributors like AT&T are much less worrisome than horizontal ones. Meanwhile, the Fang companies — Facebook, Amazon, Netflix and Google — now dominate the digital entertainment landscape, which makes the government’s argument that the merger of two old-media firms would fundamentally alter competition even harder to make.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

伊格尔说:“他非常、非常善于不让这些压力以任何方式破坏苹果正在努力实现的目标。库克的脑海里无疑有要操心的问题,但他确保专门从事苹果最擅长工作的人才不必操心这些问题。”
凯文·杜兰特
我发现自己很难开启一段对话
Most Catholics (60 percent) and white non-evangelical Protestants (65 percent) say they believe disasters like hurricanes and floods are the result of climate change.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

spontaneous
谅解是赢家永远不会拿走一切。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

6. Charlize Theron - $16.5 million
你经常烦躁吗?
['s?:kjuleit]

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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n. (复数)细菌
31岁的罗西每天的工作就是计算五角大楼在养老、医疗和教育福利方面未来的成本。但他说,这份工作不仅仅是鼓捣电子表格数据。他还要与其它政府部门进行沟通,并就金融模型与同事举行头脑风暴会议。

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