Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Since its launch in 2010, the 12306 ticketing system has been upgraded many times to fix bugs and provide better service during the Spring Festival travel rush, or Chunyun.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Angola, Zimbabwe and Albania experienced the largest increases across all the countries surveyed. "On a regional basis, by far the largest gains in life evaluations in terms of the prevalence and size of the increases have been in Latin America and the Caribbean, and in Sub-Saharan Africa", the report said. Reduced levels of corruption also contributed to the rise.
6. Charlize Theron - $16.5 million
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
The first chart shows the total incidence of banking, currency and debt default crises in emerging markets since the 1970s, set against the nominal federal funds rate. Mr Koepke gives this as evidence that high and rising rates typically precede periods of EM crisis.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Other engines cited among 2014’s best include turbodiesels in the BMW 5 Series luxury sedan and the compact Chevrolet Cruze, the horizontally opposed 2.7-liter six-cylinder in the Porsche Cayman two-seat sports coupe and the 1.8-liter turbo-four in the compact Volkswagen Jetta sedan.
Trends and targets in antiviral phototherapy
Lopez Short is the name of the game, judging from the red carpet looks of Beyoncé and Jennifer Lopez. Both divas went for thigh-high dresses to show off their gams4, with strategically cut out neck and shoulder detail, but where Beyoncé opted to stand out in fire engine red, J. Lo went for soft and satiny earth tones.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
But now she's using her storybook looks for good, dressing up as the character to entertain children and cheer-up cancer patients.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Wang Jie, the general manager of a Beijing-based investment company, said the higher pay for executives in the financial and real estate industries shows the imbalance of development in China.
ACE2 as a potential therapeutic target for pandemic COVID-19
If managers suspect you're looking elsewhere, your LinkedIn profile is often the first place they'll snoop, says Jenny Foss, founder of the career blog JobJenny.com and author of "Ridiculously Awesome Job Search Kit." "It's where a lot of people tend to get busted," she adds。
In this April 24, 1984, file photo, from left, Steve Jobs, chairman of Apple Computers, John Sculley, president and CEO, and Steve Wozniak, co-founder of Apple, unveil the new Apple IIc computer in San Francisco
Diagnostic technologies for COVID-19: a review
General Motors is helping fuel the improved jobs outlook in the Grand Canyon State. In March, the automaker announced plans to build the company’s fourth Information Technology Innovation Center in Phoenix suburb Chandler. GM is expected to hire 1, 000 workers, mainly consisting of software developers, database administrators and systems analysts for the new center. “The greater Phoenix area is a fantastic hub of emerging technical talent – from university graduates to working professionals, ” said GM CIO Randy Mott in a release announcing the move.
The strength of Kellogg/HKUST is the quality of its participants.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
富达国际(Fidelity International)旗下全球地产基金的投资组合经理德克?菲利帕(Dirk Philippa)也削减了在香港的投资，把配置比重从两年前相对基准超配6%至8%调整至超配1%。
The main culprit for the deceleration was food, though food inflation is higher than the overall index. Food prices were up 1.9 per cent in October, down from 2.7 per cent in September and 3.7 per cent in August. Non-food inflation ticked down 0.9 per cent from 1.0 per cent.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
迷你剧集/电影类最佳男演员：考特尼?B?万斯(Courtney B Vance)，《美国罪案故事：公诉辛普森》(The People v. O. J. Simpson: American Crime Story)
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Stand: Apple CEO Tim Cook fought for workplace protection for the LGBT community
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
You’re a busy person. At times, it all can feel overwhelming. Asana is a cloud-based project management software that helps you keep it together. (Trust me, I’ve tried them all.) Flexibility is built into Asana’s architecture. Each “task”, or “subtask”, can be associated with a larger “project” and “department.” In addition, you can even assign recurring tasks to yourself or team, which makes life so much easier. Stop trying to remember all the things you’re supposed to do and let Asana structure your life.
Christopher Nolan's World War II feature is probably just about the front runner for best film.
Tony Moloney, head of education and skills at National Grid, says the UK utility’s involvement is part of its broader strategy to encourage school students to study Stem subjects — science, technology, engineering and mathematics — and learn more about jobs in his sector.
Influenza neuraminidase: A druggable target for natural products
Payouts also varied substantially between industries and cities. The average bonus at financial institutions was over Rmb17,200, while those in the education sector got less than half of that on average at less than Rmb7,500.
The Producer Price Index (PPI), which gauges factory-gate prices and is a major indicator of economic briskness, rose by 6.3% in 2017, compared with a minus 1.4% for 2016, reversing the trend of continual decline since 2012.
Hong Kong has topped the list for the past seven years -- since its first appearance in the survey.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Cullinan and Ruiz each carry a suitcase containing a copy of the winning envelope for all the categories - meaning there are two envelopes for each award.
The role of biosensors in the detection of emerging infectious diseases
6. “The Martian” With its red-rock buttes and mesas, Ridley Scott’s deeply satisfying space western both draws from an enduring genre and his own Pantheon legacy. (Read the review.)
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Attractions: Paradise within reach.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
? Dozens were killed, hundreds of miles of coastline were flooded and New York City's infrastructure was dealt a massive blow as the super-storm Sandy moved through the mid-Atlantic states on Monday night and into Tuesday. Millions of people were left without power.
The U.S. $10 bill will feature the portrait of a notable U.S. woman by 2020.
Interestingly, BRICS bloc has reduced their exposure to these securities at a time when America's economic activity is expanding at a moderate rate.
Rents at the top end of the market have fallen 6.4 per cent, more sharply than in any other city except Nairobi, according to Knight Frank, the property company. Last year, just after prices fell in September, Adidas, the sportswear group, leased a 13,000 square foot shop in the city for 22 per cent less than its former occupier, Coach, the accessories brand.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
12月8日，佳士得(Christie’s)的双年夜间拍卖会仅拍得650万英镑（含佣金），约合970万美元，而最低预估价为1270万英镑。45件作品中有19件流拍，比例达42%，包括两幅估价最高的作品——阿尔布雷特·丢勒(Albrecht Dürer)的学生汉斯·霍夫曼(Hans Hoffmann)1582年创作的水彩习作——丛林中的野兔，还有弗朗西斯科·瓜尔迪(Francesco Guardi)在18世纪70年代创作的描绘威尼斯圣乔治马焦雷岛美景的油画，这两幅画的最低估价分别是400万英镑和150万英镑。
Committee Chairman Thorbjoern Jagland praised the work of the three recipients, saying that "we cannot achieve lasting peace in the world unless women obtain the same opportunities as men."
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Here are the news events that the search engine Baidu says most captured Internet users' attention in 2015:
No Bad Manners Awards could be complete without a mention of a Kardashian, could it?
In Sex and the City, Miranda and Carrie frequent a place called Magnolia Bakery at 401 Bleeker Street. After the episodes aired, hordes of people had to investigate those cupcakes. Nothing can incur cupcake mania quite like Carrie Bradshaw can. Magnolia Bakery received a huge boost in sales and customers. In fact, they were so popular that they had to hire a "bouncer" of sorts. Not quite your typical club bouncer, this bouncer was friendly and very interested in the finer points of cupcakes.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Some hits have gone so far over the top they should be winded, yet instead keep on puffing gusts of hot air, including “Downton Abbey,” “Scandal” and “Revenge.” A new addition on ABC, “How to Get Away With Murder” was a fun substitute, a lurid nighttime soap opera about lawbreaking defense lawyers — “Law & Disorder.”
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Murietta belonged to a gang known as the Five Joaquins, who were notorious bandits during the height of the California Gold Rush. While Murietta's criminal activity likely did not have any political undertones, he nonetheless became a symbol of Mexican resistance as American settlers ventured to California. Unfortunately for him, this pushed the government to put a bounty on his head, leading to his murder and beheading. Luckily, Banderas's character didn't fall to the same fate.
The highest ranked of these is Fudan University School of Management in Shanghai at 40, down eight places on its previous rank in 2014.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
出手阔绰的美国公司正迫使英国同行提高从新入行者到顶级风云人物的薪资——尽管这并未阻止富尔德(Freshfields)的私募股权明星戴维希金斯(David Higgins)在圣诞节前夕跳槽到凯易律师事务所(Kirkland & Ellis)。精品专业律所通过提供更快、更专注的服务来吸引客户。
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
《一记耳光》(The Slap)，NBC，2月12日播出。乔恩·罗宾·贝茨(Jon Robin Baitz)与丽莎·查罗登科(Lisa Cholodenko)担任制作人，这部剧改编自一部澳大利亚迷你剧，讲述一个后院生日派对失控后带来的后果。演员阵容非常强大，包括彼得·萨斯加德(Peter Sarsgaard)、乌玛·瑟曼(Uma Thurman)、桑迪·牛顿(Thandie Newton)、布莱恩·考克斯(Brian Cox)和梅丽莎·乔治（Melissa George，她也在原剧中出演角色）。
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
米兰达·兰伯特，《浴室水槽》(Bathroom Sink)，RCA Nashville
On the a monthly basis prices fell by an average 0.5 per cent.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The controlled test takes two-and-a-half hours and, according to theories, Nishi's score and subsequentIQ of 162 would be two points higher than famous physicist Einstein.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
A New Year greeting to cheer you, my good friend.希望新年祝福给你带来欢乐，我的好朋友。
It was a rare glimpse into his closely guarded personal life that also put at risk Apple’s brand in less tolerant parts of the world. Mr Cook was driven to take a stand by his experiences growing up in Alabama, where he has talked of seeing discrimination that “literally would make me sick”.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Summly的一个早期版本──Trimit，于2011年7月出现在了苹果app store“新品推荐”栏目中。正是在这里，它被极具影响力的硅谷《科技博客》(TechCrunch)所关注，并迅速引起了李嘉诚的投资集团的注意。当达洛伊西奥收到李嘉诚的维港投资(Horizons Ventures)发来的电子邮件时，他只有15岁，并且基本没让什么人知道他所做的事情。在那之前，他从未与科技领域内的任何人物见过面，而他在Trimit的登记信息中也只是粗略形容自己是“伦敦的一家科技公司”。仅靠这一信息，谁也不会想到这家公司的管理和技术团队──事实上，它的全部职员──竟然是住在郊区卧室里的一个连车都不能开的小孩。
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Always wanted to be an author but not sure where to start? Have you considered self-publishing? Thanks to Amazon, you can. Kindle Direct Publishing allows you to get the word out via e-books, CreateSpacehelps you develop a print edition and ACX is the audio publishing division. I’ve used all three to develop my book.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
For: The National Board of Review gave it their best film, actor and actress awards.
Chinese tourism to South Korea has boomed in recent years, delighting retailers but irking domestic tourists who have found the country’s attractions swamped with visitors.
A modular microarray imaging system for highly specific COVID-19 antibody testing
《小镇疑云》，BBC America，3月4日播出。大卫·田纳特(David Tennant)携第二季归来，在这部引人共鸣的英国推理剧中继续饰演亚力克·哈迪(Alec Hardy)探员（去年他在美国翻拍版的《小镇疑云》[Gracepoint]中饰演埃米特·卡弗探员）。这部剧将于周一在英国首映，制作人们已经开始谈起第二季的秘密情节了，编剧克里斯·齐布纳尔(Chris Chibnall)在接受英国杂志采访时说的话可能会让剧迷不爱听，“第二季不是讲罪案的。”奥莉薇娅·科尔曼(Olivia Colman)继续饰演艾丽·米勒(Ellie Miller)探员，夏洛特·兰普林(Charlotte Rampling)和玛丽安娜·琼-巴普迪斯特(Marianne Jean-Baptiste)也加入了演员阵容。
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
James Bond Themes 8. "You Only Live Twice" by Nancy Sinatra
The pandas did some tai-chi in Trafalgar Square before kicking on at a panda party in Convent Garden as part of the first ever Panda Awareness Week.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
We will do more to energize the non-public sector.
The Office for National Youth Campus Football said that China already had 13,381 "special football schools" as of 2016, and 69 counties are piloting programs for football in schools, the Xinhua News Agency reported.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
“Airbnb is here to stay,” Mr. Gottsegen said. “Instead of fighting it, we should wrap our arms around it and make it better.”
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
2. You've suddenly become a Twitter thought leader。
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
May the New Year be a time of laughter and real enjoyment for you. Best wishes.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
There are no right or wrong answers, just be honest with yourself.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
France, one of the most visited countries in the world, ranks No. 9 overall. It is No. 2 in Cultural Influence and No. 6 in Power.
Anti-HIV drug repurposing against SARS-CoV-2
Developer:Dontnod Entertainment, Square Enix
Two days ago here in Brazil, we were shocked when we spent some time with some children living on the streets. And this is what one child told us: "I wish I was rich and if I were, I would give all the street children food, clothes, medicine, shelter and love and affection." 在巴西，我被2天前见到的情景震惊了，那时我和当地的小孩在玩耍，其中一个小孩说：“我希望我能富裕起来，然后我会给这个街道所有的小孩饭吃，给他们衣服穿，医疗，住房和爱”。
Length-scale dependence of protein hydration-shell density
The world got by in 2013 with fewer confidence-shaking moments than in prior years. But the vulnerabilities haven't disappeared. 'It's not a great story anywhere, though it's more hopeful than it has been,' said Jerry Webman, chief economist at OppenheimerFunds.
SIZE: 6,364 square feet
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
China must walk a narrow line at a time when its outgoing leadership is reluctant to take any far-sighted decisions.
CareerCast.com, a career website owned by Adicio Inc., ranked 200 jobs from best to worst based on five criteria: physical demands, work environment, income, stress, and hiring outlook. The firm used data from the Bureau of Labor Statistics and other government agencies to determine the rankings. As in prior years, the 200 jobs were selected for their relevance in the current labor market as well as the availability of reliable data.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The life expectancy of the average human has increased more in the past 50 years than it did in the 200,000 years of human existence. Life expectancy is now 70 years old – which is a big difference from 47 years old in 1950!
Just because the job market is tough doesn't mean it's impossible. "You have to work harder at the job search," Challenger said.
Adriana Lima, 36, came in fourth place with earnings of $10.5 million, with new mother Rosie Huntington-Whiteley ($9.5 million) and Karlie Kloss, 25, ($9 million) rounding things off in sixth and seventh places, respectively.
About this collection
People promoting driverless cars, the most hyped industry segment of the moment, became world leaders in verbiage. Elon Musk claimed to be “laser-focused on achieving full self-driving capability on one integrated platform with an order of magnitude greater safety than the average manually driven car” (ie Tesla cars must stop crashing).